It's true, all roads do lead to Rome

And, of course, the reverse is also true, especially if you are travelling to Amandola in central Italy.  If you are brave enough to drive on the "wrong" side of the road and confront the Italian drivers, there are plenty of hire-cars at da Vinci aiport. However, if you fancy a more relaxed way of getting to Amandola, then catch the START bus that leaves twice daily (except Sundays) from outside 84 Viale Castro Pretorio, in the centre of Rome.  The trip takes about 4 hours and is cheap, comfortable and stress-free. As you wind through the mountain villages of the Sibillinis, you will succumb to the splendour of the landscape.